| First Author | Scherptong RW | Year | 2012 |
| Journal | Dev Dyn | Volume | 241 |
| Issue | 9 | Pages | 1413-22 |
| PubMed ID | 22826212 | Mgi Jnum | J:186546 |
| Mgi Id | MGI:5432623 | Doi | 10.1002/dvdy.23833 |
| Citation | Scherptong RW, et al. (2012) Morphogenesis of outflow tract rotation during cardiac development: The pulmonary push concept. Dev Dyn 241(9):1413-22 |
| abstractText | Background: Understanding of cardiac outflow tract (OFT) remodeling is essential to explain repositioning of the aorta and pulmonary orifice. In wild type embryos (E9.5-14.5), second heart field contribution (SHF) to the OFT was studied using expression patterns of Islet 1, Nkx2.5, MLC-2a, WT-1, and 3D-reconstructions. Abnormal remodeling was studied in VEGF120/120 embryos. Results: In wild type, Islet 1 and Nkx2.5 positive myocardial precursors formed an asymmetric elongated column almost exclusively at the pulmonary side of the OFT up to the pulmonary orifice. In VEGF120/120 embryos, the Nkx2.5-positive mesenchymal population was disorganized with a short extension along the pulmonary OFT. Conclusions: We postulate that normally the pulmonary trunk and orifice are pushed in a higher and more frontal position relative to the aortic orifice by asymmetric addition of SHF-myocardium. Deficient or disorganized right ventricular OFT expansion might explain cardiac malformations with abnormal position of the great arteries, such as double outlet right ventricle. Developmental Dynamics 241:1413-1422, 2012. (c) 2012 Wiley Periodicals, Inc. |
