| First Author | LeVine AM | Year | 2001 |
| Journal | J Immunol | Volume | 167 |
| Issue | 10 | Pages | 5868-73 |
| PubMed ID | 11698462 | Mgi Jnum | J:72681 |
| Mgi Id | MGI:2153394 | Doi | 10.4049/jimmunol.167.10.5868 |
| Citation | LeVine AM, et al. (2001) Surfactant protein D enhances clearance of influenza A virus from the lung in vivo. J Immunol 167(10):5868-73 |
| abstractText | Mice lacking surfactant protein surfactant protein D (SP-D(-/-)) and wild-type mice (SP-D(+/+)) were infected with influenza A virus (IAV) by intranasal instillation. IAV infection increased the endogenous SP-D concentration in wild-type mice. SP-D-deficient mice showed decreased viral clearance of the Phil/82 strain of IAV and increased production of inflammatory cytokines in response to viral challenge. However, the less glycosylated strain of IAV, Mem/71, which is relatively resistant to SP-D in vitro, was cleared efficiently from the lungs of SP-D(-/-) mice. Viral clearance of the Phil/82 strain of IAV and the cytokine response were both normalized by the coadministration of recombinant SP-D. Since the airway is the usual portal of entry for influenza A virus and other respiratory pathogens, SP-D is likely to play an important role in innate defense responses to IAV. |
