| First Author | Ilkovitch D | Year | 2012 |
| Journal | Anticancer Res | Volume | 32 |
| Issue | 10 | Pages | 4263-70 |
| PubMed ID | 23060546 | Mgi Jnum | J:312066 |
| Mgi Id | MGI:6782774 | Citation | Ilkovitch D, et al. (2012) uPA and uPA-receptor are involved in cancer-associated myeloid-derived suppressor cell accumulation. Anticancer Res 32(10):4263-70 |
| abstractText | BACKGROUND: Myeloid-derived suppressor cells (MDSC) have been shown to play a critical role in tumor-induced immunosuppression, in many mouse and human cancers. The aim of this study was to show that MDSC accumulation is tumor burden-dependent, and to investigate the role of the tumor-derived urokinase plasminogen activator (uPA) and its receptor (uPAR) on MDSC recruitment. MATERIALS AND METHODS: Levels of MDSC were assessed in tumor-bearers, and the ability to recruit MDSC by uPA was investigated in normal, tumor-bearers, uPAR(-/-), and CD11b(-/-) mice. uPAR expression in MDSC was also explored. RESULTS: MDSC accumulate to dramatic levels in tumor-bearers, and tumor-derived factors such as uPA also increase to great levels in circulation. MDSC can be recruited by uPA, and uPAR but not CD11b are required for such recruitment. CONCLUSION: MDSC accumulation is tumor burden-dependent, and tumor-derived factors such as uPA and its receptor uPAR play a role in their recruitment. |
