| First Author | Morancho A | Year | 2015 |
| Journal | J Cereb Blood Flow Metab | Volume | 35 |
| Issue | 10 | Pages | 1547-51 |
| PubMed ID | 26219597 | Mgi Jnum | J:312161 |
| Mgi Id | MGI:6783193 | Doi | 10.1038/jcbfm.2015.180 |
| Citation | Morancho A, et al. (2015) Impaired vascular remodeling after endothelial progenitor cell transplantation in MMP9-deficient mice suffering cortical cerebral ischemia. J Cereb Blood Flow Metab 35(10):1547-51 |
| abstractText | Endothelial progenitor cells (EPCs) are being investigated for advanced therapies, and matrix metalloproteinase 9 (MMP9) has an important role in stroke recovery. Our aim was to determine whether tissue MMP9 influences the EPC-induced angiogenesis after ischemia. Wild-type (WT) and MMP9-deficient mice (MMP9/KO) were subjected to cerebral ischemia and treated with vehicle or outgrowth EPCs. After 3 weeks, we observed an increase in the peri-infarct vessel density in WT animals but not in MMP9/KO mice; no differences were found in the vehicle-treated groups. Our data suggest that tissue MMP9 has a crucial role in EPC-induced vascular remodeling after stroke. |
