| First Author | Miller HL | Year | 2003 |
| Journal | Brain Res Dev Brain Res | Volume | 145 |
| Issue | 1 | Pages | 31-8 |
| PubMed ID | 14519491 | Mgi Jnum | J:86191 |
| Mgi Id | MGI:2678978 | Doi | 10.1016/s0165-3806(03)00192-5 |
| Citation | Miller HL, et al. (2003) Atm and c-Abl cooperate in the response to genotoxic stress during nervous system development. Brain Res Dev Brain Res 145(1):31-8 |
| abstractText | The c-Abl proto-oncogene is a target of the ATM kinase after DNA double strand breaks, although the physiological significance of these signaling events is not clear. Therefore, to delineate the roles of c-Abl and Atm during mouse development we generated mice with combinations of c-Abl and Atm mutant alleles. We found that dual inactivation of Atm and c-Abl usually resulted in midgestational lethality. However, mice with three mutant alleles, c-Abl(-/-)Atm(+/-) or c-Abl(+/-)Atm(-/-), were viable but predisposed to neuro-developmental abnormalities after genotoxic insult. Thus, these genetic data link Atm and c-Abl signaling and underscore a significant interrelationship between the two during neural development. |
