| First Author | Takagi M | Year | 2015 |
| Journal | Cell Rep | PubMed ID | 25683718 |
| Mgi Jnum | J:222034 | Mgi Id | MGI:5643880 |
| Doi | 10.1016/j.celrep.2015.01.027 | Citation | Takagi M, et al. (2015) ATM Regulates Adipocyte Differentiation and Contributes to Glucose Homeostasis. Cell Rep |
| abstractText | Ataxia-telangiectasia (A-T) patients occasionally develop diabetes mellitus. However, only limited attempts have been made to gain insight into the molecular mechanism of diabetes mellitus development in A-T patients. We found that Atm(-/-) mice were insulin resistant and possessed less subcutaneous adipose tissue as well as a lower level of serum adiponectin than Atm(+/+) mice. Furthermore, in vitro studies revealed impaired adipocyte differentiation in Atm(-/-) cells caused by the lack of induction of C/EBPalpha and PPARgamma, crucial transcription factors involved in adipocyte differentiation. Interestingly, ATM was activated by stimuli that induced differentiation, and the binding of ATM to C/EBPbeta and p300 was involved in the transcriptional regulation of C/EBPalpha and adipocyte differentiation. Thus, our study sheds light on the poorly understood role of ATM in the pathogenesis of glucose intolerance in A-T patients and provides insight into the role of ATM in glucose metabolism. |
