| First Author | Jackson RJ | Year | 2003 |
| Journal | Cancer Res | Volume | 63 |
| Issue | 12 | Pages | 3021-5 |
| PubMed ID | 12810620 | Mgi Jnum | J:83967 |
| Mgi Id | MGI:2664457 | Citation | Jackson RJ, et al. (2003) p21Cip1 Nullizygosity increases tumor metastasis in irradiated mice. Cancer Res 63(12):3021-5 |
| abstractText | p21(Cip1) is a cyclin-dependent kinase inhibitor whose abundance increases in cells exposed to radiation or other DNA-damaging agents. Such increases activate a G1 checkpoint, which allows time for DNA repair before S phase entry. By inhibiting cell cycle progression, p21(Cip1) potentially suppresses tumorigenesis, and in support, we show that p21(Cip1) heterozygous and nullizygous mice develop more tumors than do wild-type mice when exposed to a single dose of gamma-irradiation. Importantly, we also show that p21(Cip1) nullizygosity increases the incidence of metastatic tumors in irradiated mice. We suggest that p21(Cip1) is haploinsufficient for tumor suppression and functions as an antimetastatic agent. |
