| First Author | Toboso-Navasa A | Year | 2020 |
| Journal | J Exp Med | Volume | 217 |
| Issue | 7 | PubMed ID | 32407433 |
| Mgi Jnum | J:295318 | Mgi Id | MGI:6457887 |
| Doi | 10.1084/jem.20191933 | Citation | Toboso-Navasa A, et al. (2020) Restriction of memory B cell differentiation at the germinal center B cell positive selection stage. J Exp Med 217(7) |
| abstractText | Memory B cells (MBCs) are key for protection from reinfection. However, it is mechanistically unclear how germinal center (GC) B cells differentiate into MBCs. MYC is transiently induced in cells fated for GC expansion and plasma cell (PC) formation, so-called positively selected GC B cells. We found that these cells coexpressed MYC and MIZ1 (MYC-interacting zinc-finger protein 1 [ZBTB17]). MYC and MIZ1 are transcriptional activators; however, they form a transcriptional repressor complex that represses MIZ1 target genes. Mice lacking MYC-MIZ1 complexes displayed impaired cell cycle entry of positively selected GC B cells and reduced GC B cell expansion and PC formation. Notably, absence of MYC-MIZ1 complexes in positively selected GC B cells led to a gene expression profile alike that of MBCs and increased MBC differentiation. Thus, at the GC positive selection stage, MYC-MIZ1 complexes are required for effective GC expansion and PC formation and to restrict MBC differentiation. We propose that MYC and MIZ1 form a module that regulates GC B cell fate. |
