| First Author | Bershtein LM | Year | 2003 |
| Journal | Bull Exp Biol Med | Volume | 135 |
| Issue | 6 | Pages | 580-1 |
| PubMed ID | 12937679 | Mgi Jnum | J:85686 |
| Mgi Id | MGI:2675945 | Doi | 10.1023/a:1025437620749 |
| Citation | Bershtein LM, et al. (2003) Mammary Tumors in HER-2/NEU Mice Are Characterized by Low Content of Estrogen Receptors-alpha and Absence of Progesterone Receptors. Bull Exp Biol Med 135(6):580-1 |
| abstractText | Transgenic mice carrying erbB2(HER-2)neu gene are characterized by high incidence of mammary adenocarcinoma. The content of estrogen receptor was no more than 10 fmol/mg protein in 8 of 14 studied tumors, while the content of progesterone receptors was even lower in all 14 studied tumors. Based on these data, we distinguish two subtypes of HER-2/neu-adenocarcinomas in mice: ER(+),PR(-) and ER(-),PR(-), which can be used for the development of new approaches to the treatment of receptor-negative mammary gland tumors. |
