| First Author | Reed JA | Year | 2005 |
| Journal | J Clin Invest | Volume | 115 |
| Issue | 11 | Pages | 3035-44 |
| PubMed ID | 16276414 | Mgi Jnum | J:102499 |
| Mgi Id | MGI:3607668 | Doi | 10.1172/JCI25681 |
| Citation | Reed JA, et al. (2005) GM-CSF action in the CNS decreases food intake and body weight. J Clin Invest 115(11):3035-44 |
| abstractText | Many proinflammatory cytokines, such as leptin, play key roles in dynamic regulation of energy expenditure and food intake. The present work tested a role for the proinflammatory cytokine GM-CSF. Central but not peripheral administration of GM-CSF to adult rats significantly decreased food intake and body weight for at least 48 hours. Similar results were observed following central administration of GM-CSF in mice. GM-CSF receptor immunoreactivity was found on neurons within the paraventricular and arcuate nuclei of the hypothalamus. GM-CSF-deficient (GM) mice weighed more and had significantly higher total body fat than wild-type (GM) mice. Energy expenditure in GM mice was decreased compared with that in GM mice. Taken together, these findings demonstrate that GM-CSF signaling in the CNS can regulate energy homeostasis. |
