| First Author | Hadji A | Year | 2014 |
| Journal | Cell Rep | Volume | 7 |
| Issue | 1 | Pages | 208-22 |
| PubMed ID | 24656822 | Mgi Jnum | J:273985 |
| Mgi Id | MGI:6274197 | Doi | 10.1016/j.celrep.2014.02.035 |
| Citation | Hadji A, et al. (2014) Death induced by CD95 or CD95 ligand elimination. Cell Rep 7(1):208-22 |
| abstractText | CD95 (Fas/APO-1), when bound by its cognate ligand CD95L, induces cells to die by apoptosis. We now show that elimination of CD95 or CD95L results in a form of cell death that is independent of caspase-8, RIPK1/MLKL, and p53, is not inhibited by Bcl-xL expression, and preferentially affects cancer cells. All tumors that formed in mouse models of low-grade serous ovarian cancer or chemically induced liver cancer with tissue-specific deletion of CD95 still expressed CD95, suggesting that cancer cannot form in the absence of CD95. Death induced by CD95R/L elimination (DICE) is characterized by an increase in cell size, production of mitochondrial ROS, and DNA damage. It resembles a necrotic form of mitotic catastrophe. No single drug was found to completely block this form of cell death, and it could also not be blocked by the knockdown of a single gene, making it a promising way to kill cancer cells. |
