|  Help  |  About  |  Contact Us

Publication : Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma.

First Author  Puzio-Kuter AM Year  2015
Journal  Cell Death Differ Volume  22
Issue  11 Pages  1785-91
PubMed ID  25822339 Mgi Jnum  J:260472
Mgi Id  MGI:6142727 Doi  10.1038/cdd.2015.27
Citation  Puzio-Kuter AM, et al. (2015) Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma. Cell Death Differ 22(11):1785-91
abstractText  Liposarcoma (LPS) is a type of soft tissue sarcoma that mostly occurs in adults, and in humans is characterized by amplifications of MDM2 and CDK4. The molecular pathogenesis of this malignancy is still poorly understood and, therefore, we developed a mouse model with conditional inactivation of PTEN and p53 to investigate these pathways in the progression of the disease. We show that deletion of these two tumor suppressors cooperate in the formation of multiple subtypes of LPS (from well-differentiated LPS to pleomorphic LPS). In addition, progression of the tumors is further characterized by the expression of D cyclins and CDK4/6, which allow for continued cell division. Microarray analysis also revealed novel genes that are differentially expressed between different subtypes of LPS, which could aid in understanding the disease and to unravel potential new therapeutic targets.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

6 Bio Entities

Trail: Publication

0 Expression