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Allele : Rb1<tm2Brn> RB transcriptional corepressor 1; targeted mutation 2, Anton Berns

Primary Identifier  MGI:1931018 Allele Type  Targeted
Attribute String  Conditional ready, No functional change Gene  Rb1
Transmission  Germline Strain of Origin  129
Is Recombinase  false Is Wild Type  false
description  Animals homozygous for the conditional floxed exon 19 allele did not show any tumor predisposition phenotype, and were of normal fertility.

Phenotypic Similarity to Human Syndrome: Glucagonoma J:216559 in double homozygous Rb1 and Trp53 conditional mutants.

molecularNote  LoxP sites flanking exon 19 were introduced to the gene by homologous recombination. The targeted allele was verified by Southern blot analysis.
  • mutations:
  • Insertion
  • synonyms:
  • flox19-RB1,
  • pRb<L2>,
  • Rb<F19>,
  • Rb<f>,
  • Rb<lox>,
  • pRb<lox>,
  • Rb<f>,
  • pRb<lox>,
  • Rb<LoxP>,
  • pRb<L2>,
  • Rb<lox>,
  • flox19-RB1,
  • Rb<LoxP>,
  • Rb<F19>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

7 Carried By

Trail: Allele

0 Driven By

223 Publication categories

Trail: Allele