Primary Identifier | MGI:1931018 | Allele Type | Targeted |
Attribute String | Conditional ready, No functional change | Gene | Rb1 |
Transmission | Germline | Strain of Origin | 129 |
Is Recombinase | false | Is Wild Type | false |
description | Animals homozygous for the conditional floxed exon 19 allele did not show any tumor predisposition phenotype, and were of normal fertility. Phenotypic Similarity to Human Syndrome: Glucagonoma J:216559 in double homozygous Rb1 and Trp53 conditional mutants. |
molecularNote | LoxP sites flanking exon 19 were introduced to the gene by homologous recombination. The targeted allele was verified by Southern blot analysis. |