| First Author | Lee N | Year | 2019 |
| Journal | Eur J Neurosci | Volume | 49 |
| Issue | 9 | Pages | 1084-1090 |
| PubMed ID | 30554447 | Mgi Jnum | J:337885 |
| Mgi Id | MGI:6783878 | Doi | 10.1111/ejn.14304 |
| Citation | Lee N, et al. (2019) Muscle ciliary neurotrophic factor receptor alpha contributes to motor neuron STAT3 activation following peripheral nerve lesion. Eur J Neurosci 49(9):1084-1090 |
| abstractText | Expression of the ciliary neurotrophic factor (CNTF) receptor essential ligand binding subunit, CNTF receptor alpha (CNTFRalpha), is induced in motor neurons and skeletal muscle following peripheral nerve lesion. We previously found muscle CNTFRalpha promotes motor neuron axon regeneration post-lesion. Both nerve lesion and CNTF administration activate motor neuron signal transducer and activator of transcription 3 (STAT3), a transcription factor implicated in axon growth, suggesting CNTF receptors may contribute to the lesion-induced STAT3 activation. However, many receptor types signal through STAT3, and if CNTF receptors contribute, motor neuron receptors seemed most likely to regulate motor neuron STAT3. To determine the role played by muscle CNTFRalpha, we used in vivo, muscle-specific CNTFRalpha depletion in mice and report here that this selectively impairs the second phase, sustained motor neuron STAT3 activation post-lesion. Thus, muscle CNTFRalpha makes an essential contribution to motor neuron STAT3 activation during axon regeneration and may thereby promote axon regeneration through such signaling. We also report CNTFRalpha quantitative PCR suggesting involvement of many denervated muscle types, as well as muscle damaged at the lesion site. The present data add to the evidence suggesting that enhancing muscle CNTFRalpha expression may promote motor neuron regeneration in trauma and disease. |
