| First Author | Engblom D | Year | 2007 |
| Journal | Genes Dev | Volume | 21 |
| Issue | 10 | Pages | 1157-62 |
| PubMed ID | 17504935 | Mgi Jnum | J:121556 |
| Mgi Id | MGI:3710454 | Doi | 10.1101/gad.426007 |
| Citation | Engblom D, et al. (2007) Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression. Genes Dev 21(10):1157-62 |
| abstractText | The glucocorticoid receptor regulates transcription through DNA binding as well as through cross-talk with other transcription factors. In hepatocytes, the glucocorticoid receptor is critical for normal postnatal growth. Using hepatocyte-specific and domain-selective mutations in the mouse we show that Stat5 in hepatocytes is essential for normal postnatal growth and that it mediates the growth-promoting effect of the glucocorticoid receptor through a direct interaction involving the N-terminal tetramerization domain of Stat5b. This interaction mediates a selective and unexpectedly extensive part of the transcriptional actions of these molecules since it controls the expression of gene sets involved in growth and sexual maturation. |
