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Publication : Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers.

First Author  Karst H Year  2000
Journal  Nat Neurosci Volume  3
Issue  10 Pages  977-8
PubMed ID  11017168 Mgi Jnum  J:109540
Mgi Id  MGI:3629259 Doi  10.1038/79910
Citation  Karst H, et al. (2000) Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers. Nat Neurosci 3(10):977-8
abstractText  Glucocorticoids are secreted from the adrenal gland in very high amounts after stress. In the brain, these stress hormones potently modulate ionic currents, monoaminergic transmission, synaptic plasticity and cellular viability, most notably in the hippocampus where corticosteroid receptors are highly enriched. Here we show that at least some of these actions require DNA binding of glucocorticoid receptor (GR) homodimers.
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