| First Author | Guo L | Year | 2001 |
| Journal | Nat Immunol | Volume | 2 |
| Issue | 5 | Pages | 461-6 |
| PubMed ID | 11323701 | Mgi Jnum | J:69099 |
| Mgi Id | MGI:1934050 | Doi | 10.1038/87778 |
| Citation | Guo L, et al. (2001) Disrupting Il13 impairs production of IL-4 specified by the linked allele. Nat Immunol 2(5):461-6 |
| abstractText | Interleukin 13-deficient (IL-13-/-) mice express a defect in priming for IL-4 production that is not corrected by adding IL-13 to the priming culture. This is partly accounted for by the consumption of IL-4 without endogenous replacement during culture of IL-13-/- CD4+ T cells. We examined cells from mice in which disrupted Il13 was linked to wild-type Il4 on one chromosome and wild-type Il13 was linked to a 'knocked-in' green fluorescent protein (Gfp) gene in the Il4 locus. Our results show that the deficit in IL-4 production was due, at least in part, to a cis effect, in which disrupted Il13 diminished IL-4 production from the linked Il4 gene. |
