Primary Identifier | MGI:1932081 | Allele Type | Targeted |
Attribute String | Null/knockout, Reporter | Gene | Kmt2a |
Transmission | Germline | Strain of Origin | 129S2/SvPas |
Is Recombinase | false | Is Wild Type | false |
description | A posterior shift in the anterior boundaries of expression of Hoxa7 and Hoxc9 occurs in Mlltm1Sjk heterozygotes, while expression of these genes is completely abolished in homozygous nulls (J:29958). |
molecularNote | A lacZ-neomycin resistance cassette was inserted in-frame into exon 3b and placed lacZ under control of the endogenous promoter. RT-PCR studies of homozygous E10.5 embryos showed that trancripts lacking the sequences encoding the functional domains were produced from this allele. |