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Allele : Kmt2a<tm1Sjk> lysine (K)-specific methyltransferase 2A; targeted mutation 1, Stanley J Korsmeyer

Primary Identifier  MGI:1932081 Allele Type  Targeted
Attribute String  Null/knockout, Reporter Gene  Kmt2a
Transmission  Germline Strain of Origin  129S2/SvPas
Is Recombinase  false Is Wild Type  false
description  A posterior shift in the anterior boundaries of expression of Hoxa7 and Hoxc9 occurs in Mlltm1Sjk heterozygotes, while expression of these genes is completely abolished in homozygous nulls (J:29958).
molecularNote  A lacZ-neomycin resistance cassette was inserted in-frame into exon 3b and placed lacZ under control of the endogenous promoter. RT-PCR studies of homozygous E10.5 embryos showed that trancripts lacking the sequences encoding the functional domains were produced from this allele.
  • mutations:
  • Insertion
  • synonyms:
  • MLL-,
  • MLL-
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

15 Publication categories

Trail: Allele