| First Author | Abel B | Year | 2005 |
| Journal | J Immunol | Volume | 175 |
| Issue | 9 | Pages | 6006-13 |
| PubMed ID | 16237095 | Mgi Jnum | J:119351 |
| Mgi Id | MGI:3701892 | Doi | 10.4049/jimmunol.175.9.6006 |
| Citation | Abel B, et al. (2005) Osteopontin is not required for the development of Th1 responses and viral immunity. J Immunol 175(9):6006-13 |
| abstractText | Osteopontin (OPN) has been defined as a key cytokine promoting the release of IL-12 and hence inducing the development of protective cell-mediated immunity to viruses and intracellular pathogens. To further characterize the role of OPN in antiviral immunity, OPN-deficient (OPN-/-) mice were analyzed after infection with influenza virus and vaccinia virus. Surprisingly, we found that viral clearance, lung inflammation, and recruitment of effector T cells to the lung were unaffected in OPN-/- mice after influenza infection. Furthermore, effector status of T cells was normal as demonstrated by normal IFN-gamma production and CTL lytic activity. Moreover, activation and Th1 differentiation of naive TCR transgenic CD4+ T cells by dendritic cells and cognate Ag was normal in the absence of OPN in vitro. Contrary to a previous report, we found that OPN-/- mice mounted a normal immune response to Listeria monocytogenes. In conclusion, OPN is dispensable for antiviral immune responses against influenza virus and vaccinia virus. |
