| First Author | Marsh BC | Year | 2007 |
| Journal | Neuroreport | Volume | 18 |
| Issue | 2 | Pages | 153-7 |
| PubMed ID | 17301681 | Mgi Jnum | J:120346 |
| Mgi Id | MGI:3706298 | Doi | 10.1097/WNR.0b013e328010d4fa |
| Citation | Marsh BC, et al. (2007) Osteopontin expression and function within the dorsal root ganglion. Neuroreport 18(2):153-7 |
| abstractText | Osteopontin expression has previously been demonstrated in the adult rat dorsal root ganglion, although its function remains unclear. Here, we demonstrate, using real-time reverse transcription-polymerase (RT-PCR) chain reaction, that osteopontin mRNA expression is increased 1 and 3 weeks following sciatic nerve section (axotomy). Further, immunohistochemical staining suggests that this increase is restricted to neurons already expressing the protein. Osteopontin knock-out animals have significantly increased mechanosensory thresholds in the intact adult compared with the wild-type controls; however no differences in allodynia are noted between genotypes using a model of neuropathic pain. Lastly, exogenous recombinant osteopontin has no effect on neurite outgrowth from adult wild-type sensory neurons, nor were differences in neurite outgrowth observed in osteopontin knock-out animals compared with wild-type controls. |
