| Primary Identifier | MGI:1932086 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Numb |
| Transmission | Germline | Strain of Origin | 129X1/SvJ |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Mice homozygous for the Numbtm1Ynj allele were mated with transgenic mice which express Cre recombinase under the control of the beta-actin promoter. The presence of Cre resulted in germline deletion of sequences in exons 5 and 6 of the Numb gene that encode the middle portion of the phosphotyrosine binding domain of the protein. C terminus immunoreactivity was not detected in protein extracts from homozygous mutant 10.5 day embryos. |
