| First Author | Kaya Z | Year | 2005 |
| Journal | Immunology | Volume | 114 |
| Issue | 4 | Pages | 493-8 |
| PubMed ID | 15804286 | Mgi Jnum | J:97436 |
| Mgi Id | MGI:3575453 | Doi | 10.1111/j.1365-2567.2004.02113.x |
| Citation | Kaya Z, et al. (2005) Complement receptors regulate lipopolysaccharide-induced T-cell stimulation. Immunology 114(4):493-8 |
| abstractText | Complement receptors type 1 and 2 (CR1 (CD35)/CR2 (CD21)) are known to enhance the adaptive immune response. In mice, CR1/CR2 are expressed on B cells, follicular dendritic cells, and activated granulocytes. Recently, we showed that a subset of CD44high and CD62Llow T cells also expresses CR1 and CR2. We now report that CR1/CR2 are detectable on both CD4+ and CD8+ subsets of T cells. Lipopolysaccharide (LPS) from Gram-negative bacteria causes polyclonal activation of B cells and stimulation of macrophages and other antigen-presenting cells. We further demonstrate that LPS induced marked up-regulation of CD25 and CD69 on T cells from CR1/CR2 sufficient (Cr+/+), but significantly lower up-regulation on T cells from CR1/CR2 deficient (Cr-/-) mice. These findings point to a novel mechanism by which CR1/CR2 modulates the activation of T cells by LPS. |
