| First Author | Roozendaal R | Year | 2009 |
| Journal | Immunity | Volume | 30 |
| Issue | 2 | Pages | 264-76 |
| PubMed ID | 19185517 | Mgi Jnum | J:146655 |
| Mgi Id | MGI:3838093 | Doi | 10.1016/j.immuni.2008.12.014 |
| Citation | Roozendaal R, et al. (2009) Conduits mediate transport of low-molecular-weight antigen to lymph node follicles. Immunity 30(2):264-76 |
| abstractText | To track drainage of lymph-borne small and large antigens (Ags) into the peripheral lymph nodes and subsequent encounter by B cells and follicular dendritic cells, we used the approach of multiphoton intravital microscopy. We find a system of conduits that extend into the follicles and mediate delivery of small antigens to cognate B cells and follicular dendritic cells. The follicular conduits provide an efficient and rapid mechanism for delivery of small antigens and chemokines such as CXCL13 to B cells that directly contact the conduits. By contrast, large antigens were bound by subcapsular sinus macrophages and subsequently transferred to follicular B cells as previously reported. In summary, the findings identify a unique pathway for the channeling of small lymph-borne antigens and chemoattractants from the subcapsular sinus directly to the B cell follicles. This pathway could be used for enhancing delivery of vaccines or small molecules for improvement of humoral immunity. |
