| First Author | Kaya Z | Year | 2001 |
| Journal | Nat Immunol | Volume | 2 |
| Issue | 8 | Pages | 739-45 |
| PubMed ID | 11477411 | Mgi Jnum | J:140006 |
| Mgi Id | MGI:3810911 | Doi | 10.1038/90686 |
| Citation | Kaya Z, et al. (2001) Contribution of the innate immune system to autoimmune myocarditis: a role for complement. Nat Immunol 2(8):739-45 |
| abstractText | Myocarditis is a principal cause of heart disease among young adults and is often a precursor of heart failure due to dilated cardiomyopathy. We show here that complement is critical for the induction of experimental autoimmune myocarditis and that it acts through complement receptor type 1 (CR1) and type 2 (CR2). We also found a subset of CD44(hi)CD62L(lo) T cells that expresses CR1 and CR2 and propose that both receptors are involved in the expression of B and T cell activation markers, T cell proliferation and cytokine production. These findings provide a mechanism by which activated complement, a key product of the innate immune response, modulates the induction of an autoimmune disease. |
