| First Author | Streeper RS | Year | 2012 |
| Journal | Aging (Albany NY) | Volume | 4 |
| Issue | 1 | Pages | 13-27 |
| PubMed ID | 22291164 | Mgi Jnum | J:232384 |
| Mgi Id | MGI:5776680 | Doi | 10.18632/aging.100424 |
| Citation | Streeper RS, et al. (2012) Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. Aging (Albany NY) 4(1):13-27 |
| abstractText | Calorie restriction results in leanness, which is linked to metabolic conditions that favor longevity. We show here that deficiency of the triglyceride synthesis enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), which promotes leanness, also extends longevity without limiting food intake. Female DGAT1-deficient mice were protected from age-related increases in body fat, tissue triglycerides, and inflammation in white adipose tissue. This protection was accompanied by increased mean and maximal life spans of ~25% and ~10%, respectively. Middle-agedDgat1-/- mice exhibited several features associated with longevity, including decreased levels of circulating insulin growth factor 1 (IGF1) and reduced fecundity. Thus, deletion of DGAT1 in mice provides a model of leanness and extended lifespan that is independent of calorie restriction. |
