| First Author | Cases S | Year | 2004 |
| Journal | Development | Volume | 131 |
| Issue | 13 | Pages | 3047-55 |
| PubMed ID | 15163627 | Mgi Jnum | J:128259 |
| Mgi Id | MGI:3766559 | Doi | 10.1242/dev.01158 |
| Citation | Cases S, et al. (2004) Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues. Development 131(13):3047-55 |
| abstractText | Mammary gland development is a complex process that is dependent on interactions between the developing mammary epithelium and the surrounding stromal tissues. We show that mice lacking the triglyceride synthesis enzyme acyl CoA:diacylglycerol transferase 1 (DGAT1) have impaired mammary gland development, characterized by decreased epithelial proliferation and alveolar development, and reduced expression of markers of functional differentiation. Transplantation studies demonstrate that the impaired development results from a deficiency of DGAT1 in both the stromal and epithelial tissues. Our findings are the first to link defects in stromal lipid metabolism to impaired mammary gland development. |
