| First Author | Pistilli EE | Year | 2013 |
| Journal | Cytokine | Volume | 61 |
| Issue | 1 | Pages | 41-5 |
| PubMed ID | 23116661 | Mgi Jnum | J:244851 |
| Mgi Id | MGI:5913630 | Doi | 10.1016/j.cyto.2012.09.025 |
| Citation | Pistilli EE, et al. (2013) IL-15Ralpha deficiency leads to mitochondrial and myofiber differences in fast mouse muscles. Cytokine 61(1):41-5 |
| abstractText | The purpose of this study was to determine mitochondrial changes in fast muscles from interleukin-15 receptor alpha knockout (IL-15RalphaKO) mice. We tested the hypothesis that fast muscles from IL-15RalphaKO mice would have a greater mitochondrial density and altered internal structure compared to muscles from control mice. In fast muscles from IL-15RalphaKO mice, mitochondrial density was 48% greater with a corresponding increase in mitochondrial DNA content. Although there were no differences in the relative size of isolated mitochondria, internal complexity was lower in mitochondria from IL-15RalphaKO mice. These data support an increase in mitochondrial biogenesis and provide direct evidence for a greater density and altered internal structure of mitochondria in EDL muscles deficient in IL-15Ralpha. |
