| First Author | Iida T | Year | 2005 |
| Journal | Neurosci Lett | Volume | 378 |
| Issue | 1 | Pages | 28-33 |
| PubMed ID | 15763167 | Mgi Jnum | J:104828 |
| Mgi Id | MGI:3612831 | Doi | 10.1016/j.neulet.2004.12.007 |
| Citation | Iida T, et al. (2005) Attenuated fever response in mice lacking TRPV1. Neurosci Lett 378(1):28-33 |
| abstractText | TRPV1, the capsaicin receptor, is expressed not only in nociceptive neurons, but also in other locations, including the hypothalamus. Studies involving systemic or intrahypothalamic capsaicin administration have suggested a role for TRPV1 in body temperature control. To explore this possibility, we examined thermoregulatory responses in TRPV1-/- mice. These mutant animals exhibited no obvious changes in circadian body temperature fluctuation, tolerance to increased (35 degrees C) or decreased (4 degrees C) ambient temperature or ethanol-induced hypothermia. In contrast, fever production in response to the bacterial pyrogen, lipopolysaccharide (LPS) was significantly attenuated in TRPV1-/- mice. Despite this finding, we detected no significant differences between TRPV1-/- and control mice in the extent of LPS-induced c-Fos expression in numerous fever-related brain subregions. These results suggest that TRPV1 participates in the generation of polyphasic fever, perhaps at sites outside the brain. |
