| First Author | Paricio-Montesinos R | Year | 2020 |
| Journal | Neuron | Volume | 106 |
| Issue | 5 | Pages | 830-841.e3 |
| PubMed ID | 32208171 | Mgi Jnum | J:294590 |
| Mgi Id | MGI:6449563 | Doi | 10.1016/j.neuron.2020.02.035 |
| Citation | Paricio-Montesinos R, et al. (2020) The Sensory Coding of Warm Perception. Neuron 106(5):830-841.e3 |
| abstractText | Humans detect skin temperature changes that are perceived as warm or cool. Like humans, mice report forepaw skin warming with perceptual thresholds of less than 1 degrees C and do not confuse warm with cool. We identify two populations of polymodal C-fibers that signal warm. Warm excites one population, whereas it suppresses the ongoing cool-driven firing of the other. In the absence of the thermosensitive TRPM2 or TRPV1 ion channels, warm perception was blunted, but not abolished. In addition, trpv1:trpa1:trpm3(-/-) triple-mutant mice that cannot sense noxious heat detected skin warming, albeit with reduced sensitivity. In contrast, loss or local pharmacological silencing of the cool-driven TRPM8 channel abolished the ability to detect warm. Our data are not reconcilable with a labeled line model for warm perception, with receptors firing only in response to warm stimuli, but instead support a conserved dual sensory model to unambiguously detect skin warming in vertebrates. |
