| First Author | Xin J | Year | 2016 |
| Journal | Front Med | Volume | 10 |
| Issue | 4 | Pages | 465-472 |
| PubMed ID | 27896621 | Mgi Jnum | J:323951 |
| Mgi Id | MGI:6883065 | Doi | 10.1007/s11684-016-0482-7 |
| Citation | Xin J, et al. (2016) Distinct roles of ASIC3 and TRPV1 receptors in electroacupuncture-induced segmental and systemic analgesia. Front Med 10(4):465-472 |
| abstractText | Previous studies have demonstrated the effects of different afferent fibers on electroacupuncture (EA)-induced analgesia. However, contributions of functional receptors expressed on afferent fibers to the EA analgesia remain unclear. This study investigates the roles of acid-sensing ion channel 3 (ASIC3) and transient receptor potential vanilloid 1 (TRPV1) receptors in EA-induced segmental and systemic analgesia. Effects of EA at acupoint ST36 with different intensities on the C-fiber reflex and mechanical and thermal pain thresholds were measured among the ASIC3(-/-), TRPV1(-/-), and C57BL/6 mice. Compared with C57BL/6 mice, the ipsilateral inhibition of EA with 0.8 C-fiber threshold (0.8Tc) intensity on C-fiber reflex was markedly reduced in ASIC3(-/-) mice, whereas the bilateral inhibition of 1.0 and 2.0Tc EA was significantly decreased in TRPV1(-/-) mice. The segmental increase in pain thresholds induced by 0.3 mA EA was significantly reduced in ASIC3(-/-) mice, whereas the systemic enhancement of 1.0 mA EA was markedly decreased in TRPV1(-/-) mice. Thus, segmental analgesia of EA with lower intensity is partially mediated by ASIC3 receptor on Abeta-fiber, whereas systemic analgesia induced by EA with higher intensity is more likely induced by TRPV1 receptor on Adelta- and C-fibers. |
