| First Author | Veninga H | Year | 2011 |
| Journal | PLoS One | Volume | 6 |
| Issue | 10 | Pages | e24431 |
| PubMed ID | 21984892 | Mgi Jnum | J:178122 |
| Mgi Id | MGI:5297315 | Doi | 10.1371/journal.pone.0024431 |
| Citation | Veninga H, et al. (2011) A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense. PLoS One 6(10):e24431 |
| abstractText | BACKGROUND: In addition to its complement-regulating activity, CD55 is a ligand of the adhesion class G protein-coupled receptor CD97; however, the relevance of this interaction has remained elusive. We previously showed that mice lacking a functional CD97 gene have increased numbers of granulocytes. METHODOLOGY/RESULTS: Here, we demonstrate that CD55-deficient mice display a comparable phenotype with about two-fold more circulating granulocytes in the blood stream, the marginated pool, and the spleen. This granulocytosis was independent of increased complement activity. Augmented numbers of Gr-1-positive cells in cell cycle in the bone marrow indicated a higher granulopoietic activity in mice lacking either CD55 or CD97. Concomitant with the increase in blood granulocyte numbers, Cd55/ mice challenged with the respiratory pathogen Streptococcus pneumoniae developed less bacteremia and died later after infection. CONCLUSIONS: Collectively, these data suggest that complement-independent interaction of CD55 with CD97 is functionally relevant and involved in granulocyte homeostasis and host defense. |
