| First Author | Trousse F | Year | 2015 |
| Journal | Cereb Cortex | Volume | 25 |
| Issue | 10 | Pages | 3446-57 |
| PubMed ID | 25085881 | Mgi Jnum | J:235634 |
| Mgi Id | MGI:5796914 | Doi | 10.1093/cercor/bhu164 |
| Citation | Trousse F, et al. (2015) CXCR7 Receptor Controls the Maintenance of Subpial Positioning of Cajal-Retzius Cells. Cereb Cortex 25(10):3446-57 |
| abstractText | Cajal-Retzius (CR) cells are essential for cortical development and lamination. These pioneer neurons arise from distinct progenitor sources, including the cortical hem and the ventral pallium at pallium-subpallium boundary (PSB). CXCR4, the canonical receptor for the chemokine CXCL12, controls the superficial location of hem-derived CR cells. However, recent studies showed that CXCR7, a second CXCL12 receptor, is also expressed in CR cells at early developmental stages. We thus investigated the role of CXCR7 during CR cell development using multiple loss-of-function approaches. Cxcr7 gene inactivation led to aberrant localization of Reelin-positive cells within the pallium. In addition, Cxcr7(-/-) mice were characterized by significant accumulation of ectopic CR cells in the lateral part of the dorsal pallium compared with Cxcr4 knockout mice. Loss-of-function approaches, using either gene targeting or pharmacological receptor inhibition, reveal that CXCR7 and CXCR4 act both in CR positioning. Finally, conditional Cxcr7 deletion in cells derived from Dbx1-expressing progenitors indicates an essential role of CXCR7 in controlling the positioning of a subpopulation of PSB-derived CR cells. Our data demonstrate that CXCR7 has a role in the positioning of hem and PSB-derived CR cells, CXCL12 regulating CR cell subpial localization through the combined action of CXCR4 and CXCR7. |
