| First Author | Ara T | Year | 2003 |
| Journal | Immunity | Volume | 19 |
| Issue | 2 | Pages | 257-67 |
| PubMed ID | 12932359 | Mgi Jnum | J:85188 |
| Mgi Id | MGI:2673058 | Doi | 10.1016/s1074-7613(03)00201-2 |
| Citation | Ara T, et al. (2003) Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny. Immunity 19(2):257-67 |
| abstractText | The physiological role of SDF-1 on hematopoietic stem cells (HSCs) remains elusive. We show that colonization of bone marrow by HSCs in addition to myeloid cells is severely impaired in SDF-1(-/-) embryos by a long-term repopulation assay. Colonization of spleen by HSCs was also affected, but to a lesser extent. Enforced expression of SDF-1 under the control of vascular-specific Tie-2 regulatory sequences could completely rescue the reduction of HSCs but not myeloid cells in SDF-1(-/-) bone marrow. SDF-1 was detected in the vicinity of the vascular endothelial cells in fetal bone marrow. SDF-1 plays a critical role in colonization of bone marrow by HSCs and myeloid cells during ontogeny, and the mechanisms by which SDF-1 functions are distinct between HSCs and myeloid cells. |
