| First Author | Naruse S | Year | 1998 |
| Journal | Neuron | Volume | 21 |
| Issue | 5 | Pages | 1213-21 |
| PubMed ID | 9856475 | Mgi Jnum | J:111807 |
| Mgi Id | MGI:3654873 | Doi | 10.1016/s0896-6273(00)80637-6 |
| Citation | Naruse S, et al. (1998) Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron 21(5):1213-21 |
| abstractText | We have examined the trafficking and metabolism of the beta-amyloid precursor protein (APP), an APP homolog (APLP1), and TrkB in neurons that lack PS1. We report that PS1-deficient neurons fail to secrete Abeta, and that the rate of appearance of soluble APP derivatives in the conditioned medium is increased. Remarkably, carboxyl-terminal fragments (CTFs) derived from APP and APLP1 accumulate in PS1-deficient neurons. Hence, PS1 plays a role in promoting intramembrane cleavage and/or degradation of membrane-bound CTFs. Moreover, the maturation of TrkB and BDNF-inducible TrkB autophosphorylation is severely compromised in neurons lacking PS1. We conclude that PS1 plays an essential role in modulating trafficking and metabolism of a selected set of membrane and secretory proteins in neurons. |
