| First Author | Filali M | Year | 2012 |
| Journal | Behav Brain Res | Volume | 234 |
| Issue | 2 | Pages | 334-42 |
| PubMed ID | 22796601 | Mgi Jnum | J:191008 |
| Mgi Id | MGI:5451148 | Doi | 10.1016/j.bbr.2012.07.004 |
| Citation | Filali M, et al. (2012) Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD). Behav Brain Res 234(2):334-42 |
| abstractText | 3xTg-AD mutant mice are characterized by parenchymal Abeta plaques and neurofibrillary tangles resembling those found in patients with Alzheimer's disease. The mutants were compared with non-transgenic controls in sensorimotor and learning tests. 3xTg-AD mutants were deficient in T-maze reversal, object recognition, and passive avoidance learning. In addition, the mutants showed hypoactivity in two open-field tests, fewer fecal boli in an observation jar, and reduced enclosed arm entries and head-dipping in the elevated plus-maze. On the contrary, the mutants did not differ from controls in pain thresholds, nest-building, and various reflexes determined by the SHIRPA primary screen and were even better on the rotorod test of motor coordination. |
