| First Author | Chakravarthy B | Year | 2012 |
| Journal | Biochem Biophys Res Commun | Volume | 427 |
| Issue | 1 | Pages | 218-22 |
| PubMed ID | 22995307 | Mgi Jnum | J:190096 |
| Mgi Id | MGI:5448072 | Doi | 10.1016/j.bbrc.2012.09.056 |
| Citation | Chakravarthy B, et al. (2012) Reduction of the immunostainable length of the hippocampal dentate granule cells' primary cilia in 3xAD-transgenic mice producing human Abeta(1-42) and tau. Biochem Biophys Res Commun 427(1):218-22 |
| abstractText | The hippocampal dentate gyrus is one of the two sites of continuous neurogenesis in adult rodents and humans. Virtually all dentate granule cells have a single immobile cilium with a microtubule spine or axoneme covered with a specialized cell membrane loaded with receptors such as the somatostatin receptor 3 (SSTR3), and the p75 neurotrophin receptor (p75(NTR)). The signals from these receptors have been reported to stimulate neuroprogenitor proliferation and the post-mitotic maturation of newborn granule cells into functioning granule cells. We have found that in 6-24-months-old triple transgenic Alzheimer's disease model mice (3xTg-AD) producing both Abeta(1-42) and the mutant human tau protein tau(P301L,) the dentate granule cells still had immunostainable SSTR3- and p75(NTR)-bearing cilia but they were only half the length of the immunostained cilia in the corresponding wild-type mice. However, the immunostainable length of the granule cell cilia was not reduced either in 2xTg-AD mice accumulating large amounts of Abeta(1-42) or in mice accumulating only a mutant human tau protein. Thus it appears that a combination of Abeta(1-42) and tau protein accumulation affects the levels of functionally important receptors in 3xTg-AD mice. These observations raise the important possibility that structural and functional changes in granule cell cilia might have a role in AD. |
