| First Author | Martinet V | Year | 2015 |
| Journal | Nat Commun | Volume | 6 |
| Pages | 7089 | PubMed ID | 25953241 |
| Mgi Jnum | J:224890 | Mgi Id | MGI:5689245 |
| Doi | 10.1038/ncomms8089 | Citation | Martinet V, et al. (2015) Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8(+) T cells. Nat Commun 6:7089 |
| abstractText | CD8(+) T-cell memory phenotype and function are acquired after antigen-driven activation. Memory-like cells may also arise in absence of antigenic exposure in the thymus or in the periphery. Eomesodermin (Eomes) is a key transcription factor for the development of these unconventional memory cells. Herein, we show that type I interferon signalling in CD8(+) T cells directly activates Eomes gene expression. Consistent with this observation, the phenotype, function and age-dependent expansion of 'virtual memory' CD8(+) T cells are strongly affected in absence of type I interferon signalling. In addition, type I interferons induce a sustained expansion of 'virtual memory' CD8(+) T cells in an Eomes-dependent fashion. We further show that the development of 'innate thymic' CD8(+) T cells is dependent on the same pathway. In conclusion, we demonstrate that type I interferon signalling in CD8(+) T cells drives Eomes expression and thereby regulates the function and homeostasis of memory-like CD8(+) T cells. |
