| First Author | Harney DJ | Year | 2023 |
| Journal | Cell Rep | Volume | 42 |
| Issue | 6 | Pages | 112559 |
| PubMed ID | 37243595 | Mgi Jnum | J:338623 |
| Mgi Id | MGI:7511333 | Doi | 10.1016/j.celrep.2023.112559 |
| Citation | Harney DJ, et al. (2023) Dietary restriction induces a sexually dimorphic type I interferon response in mice with gene-environment interactions. Cell Rep 42(6):112559 |
| abstractText | Intermittent fasting (IF) is an established intervention to treat the growing obesity epidemic. However, the interaction between dietary interventions and sex remains a significant knowledge gap. In this study, we use unbiased proteome analysis to identify diet-sex interactions. We report sexual dimorphism in response to intermittent fasting within lipid and cholesterol metabolism and, unexpectedly, in type I interferon signaling, which was strongly induced in females. We verify that secretion of type I interferon is required for the IF response in females. Gonadectomy differentially alters the every-other-day fasting (EODF) response and demonstrates that sex hormone signaling can either suppress or enhance the interferon response to IF. IF fails to potentiate a stronger innate immune response when IF-treated animals were challenged with a viral mimetic. Lastly, the IF response changes with genotype and environment. These data reveal an interesting interaction between diet, sex, and the innate immune system. |
