| First Author | Carrero JA | Year | 2004 |
| Journal | J Exp Med | Volume | 200 |
| Issue | 4 | Pages | 535-40 |
| PubMed ID | 15302900 | Mgi Jnum | J:93914 |
| Mgi Id | MGI:3510263 | Doi | 10.1084/jem.20040769 |
| Citation | Carrero JA, et al. (2004) Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection. J Exp Med 200(4):535-40 |
| abstractText | Infection with Listeria monocytogenes causes lymphocyte apoptosis that is mediated by the actions of the pore-forming virulence factor listeriolysin O (LLO). Previous work showed that activated lymphocytes were highly sensitive to LLO-induced apoptosis, whereas resting lymphocytes were less susceptible. We now show that mice deficient in the type I interferon (IFN) receptor were more resistant to Listeria infection and had less apoptotic lesions than wild-type counterparts. Furthermore, treatment of resting splenic lymphocytes with recombinant IFN-alphaA enhanced their susceptibility to LLO-induced apoptosis. Together, these data suggest that type I IFN signaling is detrimental to handling of a bacterial pathogen and may enhance the susceptibility of lymphocytes undergoing apoptosis in response to bacterial pore-forming toxins. |
