| First Author | Hervas-Stubbs S | Year | 2007 |
| Journal | Blood | Volume | 109 |
| Issue | 12 | Pages | 5318-26 |
| PubMed ID | 17339421 | Mgi Jnum | J:145420 |
| Mgi Id | MGI:3834539 | Doi | 10.1182/blood-2006-10-053256 |
| Citation | Hervas-Stubbs S, et al. (2007) TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help. Blood 109(12):5318-26 |
| abstractText | We investigated whether Toll-like receptor ligands (TLR-Ls) can bypass the requirement for CD4(+) T-cell help in the induction of fully efficient memory CD8(+) T cells (cytotoxic T lymphocytes [CTLs]). 'Helpless' CTLs were induced by a synthetic CD8(+) T-cell epitope administered with TLR3-L and TLR9-L, but not with TLR2/6-L, TLR4-L, or TLR7-L. The up-regulation of MHC-I and costimulatory molecules by dendritic cells following TLR stimulation was not sufficient for the priming of 'helpless' CTLs, which depended essentially on the induction of a strong IFN-alpha/beta response. The 'helpless' CTLs induced by TLR-Ls differentiated into fully functional memory CTLs able to proliferate as well as their 'helped' counterparts upon challenge, in the absence of CD4(+) T-cell help. |
