| First Author | Nascimento M | Year | 2019 |
| Journal | Sci Rep | Volume | 9 |
| Issue | 1 | Pages | 14848 |
| PubMed ID | 31619733 | Mgi Jnum | J:284653 |
| Mgi Id | MGI:6389448 | Doi | 10.1038/s41598-019-51427-y |
| Citation | Nascimento M, et al. (2019) Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice. Sci Rep 9(1):14848 |
| abstractText | Cigarette smoke exposure is a leading cause of chronic obstructive pulmonary disease (COPD), a major health issue characterized by airway inflammation with fibrosis and emphysema. Here we demonstrate that acute exposure to cigarette smoke causes respiratory barrier damage with the release of self-dsDNA in mice. This triggers the DNA sensor cGAS (cyclic GMP-AMP synthase) and stimulator of interferon genes (STING), driving type I interferon (IFN I) dependent lung inflammation, which are attenuated in cGAS, STING or type I interferon receptor (IFNAR) deficient mice. Therefore, we demonstrate a critical role of self-dsDNA release and of the cGAS-STING-type I interferon pathway upon cigarette smoke-induced damage, which may lead to therapeutic targets in COPD. |
