| First Author | Soda N | Year | 2019 |
| Journal | J Immunol | Volume | 203 |
| Issue | 5 | Pages | 1356-1368 |
| PubMed ID | 31366715 | Mgi Jnum | J:278687 |
| Mgi Id | MGI:6357778 | Doi | 10.4049/jimmunol.1900354 |
| Citation | Soda N, et al. (2019) Singleton-Merten Syndrome-like Skeletal Abnormalities in Mice with Constitutively Activated MDA5. J Immunol 203(5):1356-1368 |
| abstractText | Singleton-Merten syndrome (SMS) is a type I interferonopathy characterized by dental dysplasia, aortic calcification, skeletal abnormalities, glaucoma, and psoriasis. A missense mutation in IFIH1 encoding a cytoplasmic viral RNA sensor MDA5 has recently been identified in the SMS patients as well as in patients with a monogenic form of lupus. We previously reported that Ifih1(gs/+) mice express a constitutively active MDA5 and spontaneously develop lupus-like nephritis. In this study, we demonstrate that the Ifih1(gs/+) mice also exhibit SMS-like bone abnormalities, including decreased bone mineral density and thin cortical bone. Histological analysis revealed a low number of osteoclasts, low bone formation rate, and abnormal development of growth plate cartilages in Ifih1(gs/+) mice. These abnormalities were not observed in Ifih1(gs/+) Mavs(-/-) and Ifih1(gs/+) Ifnar1(-/-) mice, indicating the critical role of type I IFNs induced by MDA5/MAVS-dependent signaling in the bone pathogenesis of Ifih1(gs/+) mice, affecting bone turnover. Taken together, our findings suggest the inhibition of type I IFN signaling as a possible effective therapeutic strategy for bone disorders in SMS patients. |
