| First Author | Liberatore RA | Year | 2019 |
| Journal | Elife | Volume | 8 |
| PubMed ID | 31644426 | Mgi Jnum | J:282823 |
| Mgi Id | MGI:6383755 | Doi | 10.7554/eLife.49875 |
| Citation | Liberatore RA, et al. (2019) Rhabdo-immunodeficiency virus, a murine model of acute HIV-1 infection. Elife 8:e49875 |
| abstractText | Numerous challenges have impeded HIV-1 vaccine development. Among these is the lack of a convenient small animal model in which to study antibody elicitation and efficacy. We describe a chimeric Rhabdo-Immunodeficiency virus (RhIV) murine model that recapitulates key features of HIV-1 entry, tropism and antibody sensitivity. RhIVs are based on vesicular stomatitis viruses (VSV), but viral entry is mediated by HIV-1 Env proteins from diverse HIV-1 strains. RhIV infection of transgenic mice expressing human CD4 and CCR5, exclusively on mouse CD4+ cells, at levels mimicking those on human CD4+ T-cells, resulted in acute, resolving viremia and CD4+ T-cell depletion. RhIV infection elicited protective immunity, and antibodies to HIV-1 Env that were primarily non-neutralizing and had modest protective efficacy following passive transfer. The RhIV model enables the convenient in vivo study of HIV-1 Env-receptor interactions, antiviral activity of antibodies and humoral responses against HIV-1 Env, in a genetically manipulatable host. |
