| First Author | HuangFu WC | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 21-22 | Pages | 3206-10 |
| PubMed ID | 18722370 | Mgi Jnum | J:139676 |
| Mgi Id | MGI:3809356 | Doi | 10.1016/j.febslet.2008.08.013 |
| Citation | Huangfu WC, et al. (2008) Cigarette smoking products suppress anti-viral effects of Type I interferon via phosphorylation-dependent downregulation of its receptor. FEBS Lett 582(21-22):3206-3210 |
| abstractText | While negative effect of smoking on the resistance to viral infections was known, the underlying mechanisms remained unclear. Here we report that products of cigarette smoking compromise the cellular anti-viral defenses by inhibiting the signaling induced by Type I interferon (IFN). Cigarette smoking condensate (but not pure nicotine) stimulated specific serine phosphorylation-dependent ubiquitination and degradation of the IFNAR1 subunit of the Type I IFN receptor leading to attenuation of IFN signaling and decreased resistance to viral infection. This resistance was restored in cells where phosphorylation-dependent degradation of IFNAR1 is abolished. We conclude that smoking compromises cellular anti-viral defenses via degradation of Type I IFN receptor and discuss the significance of this mechanism for efficacy of IFN-based therapies. |
