| First Author | Domínguez-Andrés J | Year | 2017 |
| Journal | Immunity | Volume | 46 |
| Issue | 6 | Pages | 1059-1072.e4 |
| PubMed ID | 28636955 | Mgi Jnum | J:254533 |
| Mgi Id | MGI:6111932 | Doi | 10.1016/j.immuni.2017.05.009 |
| Citation | Dominguez-Andres J, et al. (2017) Inflammatory Ly6C(high) Monocytes Protect against Candidiasis through IL-15-Driven NK Cell/Neutrophil Activation. Immunity 46(6):1059-1072.e4 |
| abstractText | Neutrophils play a crucial role in defense against systemic candidiasis, a disease associated with a high mortality rate in patients receiving immunosuppressive therapy, although the early immune mechanisms that boost the candidacidal activity of neutrophils remain to be defined in depth. Here, we used a murine model of systemic candidiasis to explore the role of inflammatory Ly6C(high) monocytes in NK cell-mediated neutrophil activation during the innate immune response against C. albicans. We found that efficient anti-Candida immunity required a collaborative response between the spleen and kidney, which relied on type I interferon-dependent IL-15 production by spleen inflammatory Ly6C(high) monocytes to drive efficient activation and GM-CSF release by spleen NK cells; this in turn was necessary to boost the Candida killing potential of kidney neutrophils. Our findings unveil a role for IL-15 as a critical mediator in defense against systemic candidiasis and hold promise for the design of IL-15-based antifungal immunotherapies. |
