| First Author | Larocca RA | Year | 2019 |
| Journal | Cell Host Microbe | Volume | 26 |
| Issue | 5 | Pages | 591-600.e4 |
| PubMed ID | 31668877 | Mgi Jnum | J:349994 |
| Mgi Id | MGI:7660740 | Doi | 10.1016/j.chom.2019.10.001 |
| Citation | Larocca RA, et al. (2019) Adenovirus Vector-Based Vaccines Confer Maternal-Fetal Protection against Zika Virus Challenge in Pregnant IFN-alphabetaR(-/-) Mice. Cell Host Microbe 26(5):591-600.e4 |
| abstractText | Maternal infection with Zika virus (ZIKV) can lead to microcephaly and other congenital abnormalities of the fetus. Although ZIKV vaccines that prevent or reduce viremia in non-pregnant mice have been described, a maternal vaccine that provides complete fetal protection would be desirable. Here, we show that adenovirus (Ad) vector-based ZIKV vaccines induce potent neutralizing antibodies that confer robust maternal and fetal protection against ZIKV challenge in pregnant, highly susceptible IFN-alphabetaR(-/-) mice. Moreover, passive transfer of maternal antibodies from vaccinated dams protected pups against post-natal ZIKV challenge. These data suggest that Ad-based ZIKV vaccines may be able to provide protection in pregnant females against fetal ZIKV transmission in utero as well as in infants against ZIKV infection after birth. |
