| First Author | DeKoter RP | Year | 2002 |
| Journal | Immunity | Volume | 16 |
| Issue | 2 | Pages | 297-309 |
| PubMed ID | 11869689 | Mgi Jnum | J:74716 |
| Mgi Id | MGI:2159023 | Doi | 10.1016/s1074-7613(02)00269-8 |
| Citation | DeKoter RP, et al. (2002) PU.1 Regulates Expression of the Interleukin-7 Receptor in Lymphoid Progenitors. Immunity 16(2):297-309 |
| abstractText | Development of the lymphoid system is dependent on the Ets family transcription factor PU.1. We demonstrate that PU.1(minus sign/minus sign) hematopoietic progenitors fail to express IL-7Ralpha transcripts. Promoter and chromatin crosslinking analyses suggest that PU.1 directly regulates transcription of the IL-7Ralpha gene. Retroviral transduction of IL-7Ralpha into PU.1(minus sign/minus sign) progenitors restores IL-7-dependent proliferation and induces, at low frequency, the generation of pro-B cells undergoing an apparently normal program of differentiation. Although the related factor Spi-B can substitute for PU.1 in early B cell development, it is not required. These results demonstrate that PU.1 functions to regulate early B cell development in part by controlling the expression of the IL-7Ralpha gene. |
