| First Author | Pracht K | Year | 2021 |
| Journal | Eur J Immunol | Volume | 51 |
| Issue | 5 | Pages | 1089-1109 |
| PubMed ID | 33336366 | Mgi Jnum | J:307366 |
| Mgi Id | MGI:6712051 | Doi | 10.1002/eji.202048993 |
| Citation | Pracht K, et al. (2021) miR-148a controls metabolic programming and survival of mature CD19-negative plasma cells in mice. Eur J Immunol 51(5):1089-1109 |
| abstractText | Long-lived antibody-secreting plasma cells are essential to establish humoral memory against pathogens. While a regulatory transcription factor network has been established in plasma cell differentiation, the regulatory role of miRNAs remains enigmatic. We have recently identified miR-148a as the most abundant miRNA in primary mouse and human plasma cells. To determine whether this plasma cell signature miRNA controls the in vivo development of B cells into long-lived plasma cells, we established mice with genomic, conditional, and inducible deletions of miR-148a. The analysis of miR-148a-deficient mice revealed reduced serum Ig, decreased numbers of newly formed plasmablasts and reduced CD19-negative, CD93-positive long-lived plasma cells. Transcriptome and metabolic analysis revealed an impaired glucose uptake, a reduced oxidative phosphorylation-based energy metabolism, and an altered abundance of homing receptors CXCR3 (increase) and CXCR4 (reduction) in miR-148a-deficient plasma cells. These findings support the role of miR-148a as a positive regulator of the maintenance of long-lived plasma cells. |
