| First Author | Belver L | Year | 2010 |
| Journal | Immunity | Volume | 33 |
| Issue | 5 | Pages | 713-22 |
| PubMed ID | 21093320 | Mgi Jnum | J:167003 |
| Mgi Id | MGI:4866968 | Doi | 10.1016/j.immuni.2010.11.010 |
| Citation | Belver L, et al. (2010) MicroRNAs prevent the generation of autoreactive antibodies. Immunity 33(5):713-22 |
| abstractText | MicroRNAs have been shown to be critical for a number of aspects of immune system regulation and function. Here, we have examined the role of microRNAs in terminal B cell differentiation by analyzing Cd19-Cre(ki/+) Dicer1(fl/fl) mice. We found that in the absence of Dicer, the transitional and marginal zone (MZ) B cell compartments were overrepresented and follicular (FO) B cell generation was impaired. microRNA analysis revealed that miR185, a microRNA overexpressed in FO cells, dampened B cell receptor (BCR) signaling through Bruton tyrosine kinase downregulation. Dicer-deficient B cells had a skewed BCR repertoire with hallmarks of autoreactivity, which correlated with high titers of autoreactive antibodies in serum and autoimmune features in females. Together, our results reveal a crucial role for microRNAs in late B cell differentiation and in the establishment of B cell tolerance. |
