| First Author | Sun Y | Year | 2023 |
| Journal | Int Immunopharmacol | Volume | 117 |
| Pages | 109939 | PubMed ID | 37012862 |
| Mgi Jnum | J:334737 | Mgi Id | MGI:7463688 |
| Doi | 10.1016/j.intimp.2023.109939 | Citation | Sun Y, et al. (2023) Reduction of peritoneal cavity B1a cells in adult Slc7a5 knockdown mice via dysregulating the mTOR pathway. Int Immunopharmacol 117:109939 |
| abstractText | Slc7a5 is an important amino acid transporter that is highly expressed in metabolically active and rapidly proliferating cells. To explore the effect of Slc7a5 on adult B cell development, we conditionally deleted Slc7a5 in murine B cells and observed a significant reduction of B1a cells. In contrast to PI3K-Akt pathway activation, activity of the mTOR pathway was decreased. This may result from intracellular amino acid starvation in Slc7a5 knockdown (Slc7a5 KD) bone marrow B cells, thereby dampening B1a development. RNA-seq analysis demonstrated increased translation and reduced proliferation in Slc7a5 KD bone marrow B cells. Overall, the results of our study highlight the importance of Slc7a5 in peritoneal B1a cell development. |
